Informations générales (source: ClinicalTrials.gov)
Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology - A Randomized, Controlled, Multicenter Study
Interventional
N/A
Nantes University Hospital (Voir sur ClinicalTrials)
mars 2026
mars 2028
02 avril 2026
Tumor thermal ablation under Jet Ventilation is a procedure performed under general
anesthesia that enables tumor ablation under radiological imaging guidance.
This procedure, being less invasive than conventional surgery, allows for a faster
recovery and hospital discharge. This procedure requires significant precision to ensure
the most complete destruction of the tumor, while also preserving adjacent organs. During
general anesthesia, respiratory movements complicate radiological localization and tumor
destruction.
The principle of High-Frequency Jet Ventilation (HFJV) involves using a device that
ventilates a small volume of air and oxygen at a specific pressure, called driving
pressure, at a high frequency.
This ventilation mode reduces respiratory movements while ensuring continuous ventilation
and oxygenation. This respiratory stability allows for the precision necessary to
superimpose images for tumor localization and destruction.
There are no guidelines regarding the driving pressure setting for HFJV for tumor thermal
ablation. The method tested in this research is based on patient's height to optimize the
driving pressure when using HFV.
The main objective of this research is to evaluate the impact of driving pressure
settings, on respiratory function, taking into account patient's height.
On the day of the procedure, the driving pressure setting for the HFJV will be randomly
assigned (1.4 bars, 1.9 bars, 2.4 bars, or customized according to the patient's height)
(1 bar = 14 psi).
The research will be conducted using medical data collected during routine patient care.
Patient participation will last for the duration of their hospital stay, approximately
two days.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT GUSTAVE ROUSSY | Sandrine GARDE | 07/08/2026 13:45:04 | Contacter | ||
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre Léon Bérard - 69008 - Lyon - France | Alexandre MEYER | Contact (sur clinicalTrials) | |||
| CHU de Nantes - 44093 - Nantes - France | Nathalie DESFRICHES-DORIA | Contact (sur clinicalTrials) | |||
| CHU de Poitiers - 86000 - Poitiers - France | Anne MERCIER | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CHU de Lyon - 69002 - Lyon - France | Stéphanie CLERC | Contact (sur clinicalTrials) | |||
| CHU de Nîmes - 30900 - Nîmes - France | Natacha SIMON-MONNIER | Contact (sur clinicalTrials) | |||
| ICO Unicancer - 44800 - Saint-Herblain - France | Roland MARTIN | Contact (sur clinicalTrials) | |||
Critères
Tous
- Age ≥ 18 years.
- Patient undergoing thermal ablation of a solid tumor under HFJV.
- Patient who has given their consent.
- Patient covered by a social security scheme.
Exclusion Criteria:
- Patient under guardianship or curatorship.
- Patient who does not understand French.
- Pregnant and breastfeeding woman
- Patient who has had a pneumonectomy
- Patient requiring an endotracheal tube smaller than 6.5