Informations générales (source: ClinicalTrials.gov)
Detection of Specific Polysaccharide Antibody Deficiency in Adult Patients With Unexplained Recurrent and/or Severe Bacterial Infections
Observational
University Hospital, Lille (Voir sur ClinicalTrials)
mars 2023
juin 2026
19 mai 2026
The DETECT study aims to demonstrate the importance of detecting SPAD in adult patients
with recurrent benign and/or severe unexplained bacterial upper/lower respiratory tract
infections. Unlike children in whom the deficit may be transient, long-term strategies
are warranted in SPAD adult patients to prevent severe infections and lung disability.
Beyond the diagnosis of this still unrecognized PID in adult patients, the investigators
want to assess the impact of prophylactic antibiotics or IgRT on infections prevention
and on quality of life in adult patients with the most severe clinical phenotypes,
recurrent infections with high frequency of antibiotics take and/or recurrent infections
with complications like bronchiectasis and/or severe infections requiring
hospitalizations.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | HELENE SALVATOR | 22/06/2026 07:26:03 | Contacter | ||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Lille University Hospital - 59037 - Lille - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
- 18 to 65 year old patients
- With a history of recurrent bacterial infections of upper and/or lower respiratory
tract for at least 2 years, and fulfilling the specific following criteria:
- Recurrent benign infections currently requiring 6 courses of antibiotics /year or
more, or Bilateral bronchiectasis/bronchiolitis (after exclusion of cystic fibrosis
and ciliary dyskinesia) AND recurrent benign infections currently requiring 3
courses of antibiotics /year or more or A history of severe upper/lower respiratory
tract bacterial infection, and/or invasive infection with Streptococcus pneumonia,
Streptococcus pyogenes or Haemophilus influenzae, which required hospitalization in
the last 2 years, AND recurrent benign infections currently requiring 3 courses of
antibiotics /year.
- Normal serum IgG, IgA, IgM and IgG subclasses levels, normal CH50 and serum
complement C3 and C4 proteins levels, normal T cells count
- Normal B cell count, normal serum protein electrophoresis and immunofixation. (*
excepted for Pseudomonas aeruginosa colonization)
Exclusion Criteria:
- Any general condition that predisposes to infections: solid or hematological
malignancies, diabetes mellitus, severe alcohol or intravenous drug abuse, chronic
liver or kidney failure, human immunodeficiency virus infection, anatomic or
functional asplenia, drug-induced 1 neutropenia, or solid organ or hematopoietic
stem cell transplantation;
- Any local predisposing factor to infections: cigarette smoking (> 10 pack-year
and/or 5 cigarettes/day), underlying infection (tuberculosis, influenza…), chronic
obstructive pulmonary disease, oral, dental or skin conditions favorizing
infections, streptococcal skin infections
- Any other SID or PID diagnosed before inclusion
- Pregnancy
- PPV23 administration in the last 2 years (risk of hyporesponsiveness)